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Currently Viewing: All Categories > Technology 00086
00086: Optimal Laser Desorption and Ionization Source for MALDI-TOF Mass Spectrometry
Technology Categories
Analytical Instruments, Control Systems, Photonics, Test and Measurement
Keywords
mass spectrometry, pulse shape, MALDI, TOF
Background
Matrix Assisted Laser Desorption Ionization (MALDI) mass spectrometry is a method for analyzing proteins. Conventionally, a laser of fixed frequency and pulse shape is used to ionize the proteins in a chemical matrix. However, a fixed laser limits the number of proteins that can be identified within a given matrix as the laser overexcites (i.e. destroys) many proteins. However, lasers can be controlled to vary their intensity, frequency, and pulse shape. Optimal control avoids the limitations of a fixed laser, making the variable laser more 'sample friendly' and expanding the set of proteins that can be identified in a given matrix while simultaneously improving identification.
Description
The invention is a control system that optimizes a laser source used in MALDI mass spectrometry.
Benefits
- Expanded identification: Variable laser source preserves (i.e. does not destroy) a larger set of proteins for identification.
- Improved efficiency: Optimized laser excitation simultaneously reduces time and false positives of protein identification.
- Larger set of Matrices: Variable laser source enables a larger and potentially cheaper set of matrix substrates.
- Reduced cost: Optimized variable laser source can reproduce the same results as a more expensive fixed laser.
Applications
Clinical Diagnostics, Proteomics, Drug Discovery, Forensic Analysis, Environmental Analysis
Development Status
Proof of concept
IP Protection Status
US 7106811 (issued Sep 12, 2006)
Related Technologies
Contact
For more information about this technology, please contact Bradley Shaw at 517-355-2186 or shawbr@msu.edu.